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At P50, a mid stage of cone degeneration, daily NACET administration led to significant protection of cone function (~ 31%) compared to vehicle at the highest flash intensity in photopic b-wave amplitude, as compared to the vehicle in rd10 mice model of RP (Fig

Those same mechanisms drive side effects that need monitoring

protective effects on the gastrointestinal tract (studied in models of ulcers and inflammatory injury)

First, geroscience-relevant signal is not proven longevity drug. The history of aging research is full of interventions that produced beautiful biomarker movement and zero lifespan benefit, and the discipline has spent the last decade developing the methodological seriousness to tell the difference

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GLP-1RAs improve endothelial function and enhance vascular repair by increasing both the number and activity of circulating endothelial progenitor cells (EPCs)