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Kidney Stones (Renal Calculi)

Ecotoxicol Environ Saf 249:114371

We used state-of-the-art proteomics techniques and showed that PfK13 is the only protein that is consistently less abundant in several artemisinin-resistant clinical isolates in both ring-and trophozoite-stage parasites

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Notably, TMAO also amplifies ERS markers such as heat shock protein 60 and glucose regulated protein 78kD in macrophages, correlating with elevated toll-like receptor 4 expression and proinflammatory cytokine production (e.g., TNF-, IL-6) (88, 89)