Specifically, we applied transcriptomics-driven metabolic pathway analysis (TDMPA), a method that uses genome-scale metabolic models to calculate perturbations of enzymatic reactions from gene expression data 46
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Excessive ROS can induce lipid peroxidation of fatty acids localized near mitochondria, generating reactive peroxides that exert lipotoxic effects on mitochondrial DNA (mtDNA), RNA, and proteins, thereby impairing mitochondrial function ( During lesion progression, activated microglia phagocytose iron released from degenerating oligodendrocytes, a process that may further amplify oxidative tissue damage ( Inflammation and OS are thus tightly interconnected processes in MS, forming a mutually reinforcing and self-perpetuating pathological cycle
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