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Limitations & Considerations The enrolled participants with obesity and overweight may represent a subpopulation with a greater commitment to weight-management efforts than the general population with obesity The measured baseline cardiometabolic risk factors in the trial population, such as blood pressure and lipids, were relatively normal, possibly attenuating the potential to show improvement, though meaningful changes in these variables were observed

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Gastrointestinal distress beyond nausea is the second major concern

Boxed Warning: Risk of Thyroid C-Cell Tumors In rodents, semaglutide caused thyroid C-cell tumors

Nutrients 2021, 13 (6)

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