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Clin Drug Investig 36(3):169175

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However, according to the Liraglutide Effect and Action in Diabetes (LEAD) the reduction in systolic blood pressure of 3.6-6.7mmHg occurred within 2 weeks, which resulted prior to any substantial weight loss, this effect lasted throughout the entire 26-week trial 7

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Retatrutide, a GIP, GLP-1 and glucagon receptor agonist, for people with type 2 diabetes: a randomised, double-blind, placebo and active-controlled, parallel-group, phase 2 trial. Lancet 402(10401):529544

On particularly tough days, aim for just 10 minutes of movement if it leaves you feeling worse, give yourself permission to rest for the remainder of the day