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Inclusion/Exclusion Criteria and Adverse Events were listed in Table S1a

472 Besides, ipatasertib was also tested in combination with neoadjuvant chemotherapy in the phase 2 FAIRLANE study, where this regimen showed numerically higher ORR compared to placebo

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10.1016/S0021-9673(99)00902-4 J

Supporting this, our study suggested that MeHgSG adduct undergoes S -transmercuration with reactive CysSH residues on proteins, resulting in formation of protein-MeHg adducts 15 , which are associated with the activation of redox signaling pathways and toxicity 3,4 , as mentioned above