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The AACE/ACE Obesity Clinical Practice Guidelines state directly: "Obesity is a chronic, relapsing disease process" requiring treatment strategies comparable in duration to those used for hypertension or type 2 diabetes [4]

These molecules were tested for DPP-4 inhibitory activity, with 6-methyl-5-(4-methylpyridin-2-yl)-1-phenyl-1H-pyrazolo[3,4-d] pyrimidin-4(5H)-one (compound 29) (Figure 5) showing the highest activity (IC 50 = 1.06 M)

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Role of cytochrome P450S in the generation and metabolism of reactive oxygen species

This is encouraging, but the data is observational rather than from controlled trials