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As hepatocytes do not express the GLP-1R, the benefits of semaglutide may be secondary to weight loss or indirect reflecting local or systemic actions of semaglutide to improve hepatic metabolism and inflammation (Figure 1B)
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However, Wegovy does have 5 strengths, and side effects can come back with each step up in dose
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( f ) Heatmap of HR-related genes in Ovcar8 cells
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