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There was a statistically significant reduction at two sites in the placebo group, namely the right side of the face and the sun-exposed left forearm

It's the first one

People with dietary restrictions, such as vegans and vegetarians, who may not get sufficient B12 from their diet, or those with absorption issues, like those with pernicious anemia or gastrointestinal disorders, also often qualify

Furthermore, the risk of supplement contamination is a huge problem

This ensures that researchers receive a reliable, high-integrity compound for their work, free from contaminants

It supports preparation and dilution workflows requiring consistent sterile handling