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Age, environmental or lifestyle-related factors cause oxidative stress in the male germ line, which not only disrupts the integrity of sperm DNA but also limits its fertilizing potential as a result of collateral damage to proteins and lipids in the sperm plasma membrane which might cause childhood cancers or other diseases in the next generation

Consequently, inhibition of ACSL4 or LPCAT3 reduces these oxidizable phospholipid-polyunsaturated fatty acids (PL-PUFAs), rendering cells resistant to ferroptosis (74, 75)

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However, prolonged high doses of vitamin B12 can lead to various side effects: Anaphylactic shock: This allergic reaction to vitamin B12 is rare but very dangerous, potentially leading to death