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It is a synthetic biguanide, originally derived from a guanidine compound found in Galega officinalis , a medicinal plant historically used to alleviate diabetic symptoms as early as the 18th century ( Initially, metformin attracted limited clinical interest due to its relatively low potency and the need for high doses to achieve therapeutic effects

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The tripeptide GHK is known for its capacity to bind copper ions and form a stable peptide-metal complex