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Most patients begin to notice subtle pigmentation changes after 3 to 6 months of consistent treatment

Canibano, E

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Dopamine oxidation alters mitochondrial respiration and induces permeability transition in brain mitochondria: implications for Parkinson's disease

Be concerned if clinics claim peptides have "no side effects" or are "completely safe for everyone", dismiss questions about risks or contraindications, fail to discuss potential interactions with medications or conditions, or don't provide emergency contact information for concerning symptoms

PLoS ONE 7 , e40015 (2012)