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We hypothesise that selection of region-specific AIs is favoured because mutations in those regions modulate a competitive growth advantage

At this point we would see a transition from what is viewed as non-lesional KP to the formation of an infundibular plug, resulting in tactile protrusions or bumps on the surface of the skin

Quinn, J

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In addition to genetics, environmental and societal variables are important(Bouchard & McGue, 2003)

The concept of probe-dependence [43] in which the outcome of allosteric modulation is determined by the nature of the orthosteric ligand may provide an additional area of exploitation if the signaling outcomes of allosteric modulation of metabolites differs from that of allosteric modulation of the primary, endogenous ligand as suggested by these studies