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However, it has not been conclusively established that the sulfonamide group is the sole cause of hypersensitivity reactions, as non-antibiotic sulfonamides do not share the same accessory groups with antibiotic sulfonamides

This is called glucose-dependent insulin secretion

doi: 10.1210/endo.135.4.7925114

Positional cloning of the mouse obese gene and its human homologue

J Ethnopharmacol 257:112884 Attia GM, Elmansy RA, Elsaed WM (2019) Neuroprotective effect of nilotinib on pentylenetetrazol-induced epilepsy in adult rat hippocampus: involvement of oxidative stress, autophagy, inflammation, and apoptosis [J]

If you are comparing these medicines, the practical question is not only which one produced larger average results in studies