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A caveat when interpreting our results is that in many cases we treated cells with relatively high doses of agonist in order to establish differences in maximal response

Cadmium chloride exposure specifically inhibits DNMT3A/3B activity by 70%, impairing de novo methylation processes and contributing to germline instability (89)

J Physiol (Lond) (2001) 536:37585

In addition, the activities of key enzymes that are involved in MG metabolism, including GlO1, GlO2, and D-lactate dehydrogenase, were significantly reduced in the kidney injury model, indicating a decreased MG detoxification capacity

The black box warning on GLP-1 receptor agonists stems from animal studies showing C-cell hyperplasia and medullary thyroid cancer in rodents