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In a case report of a 22-year old male patient with severe, debilitating OCD and no satisfactory response to SSRIs, five years of glycine treatment led to a large reduction in OCD symptoms, and resumption of education and social life (Cleveland 2009)

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Additionally, leptin affected the expression of antioxidative enzymes, catalase and SOD, and increased the mRNA expression of pro-inflammatory factors

A comprehensive literature search was conducted using the MEDLINE database (PubMed) for English-language articles published up to May 2025 using combinations of key search terms including diabetes mellitus, diabetes, neuropathy, polyneuropathy, diabetic neuropathies, peripheral neuropathy, diabetic polyneuropathy, pathophysiology, diagnosis and treatment. Articles were selected that primarily focused on DPN, with emphasis on human studies addressing the pathophysiology, clinical presentation, diagnostic approaches and therapeutic interventions

| v.22 | n1 | Jan-Feb-Mar/ 2018 CONCLUSION Oxidative stress occurs when the generation of reac- tive oxygen species (ROS) and other radical species over- rides the scavenging capacity of antioxidants, either due to excessive ROS production or an inadequate availability of antioxidants

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