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Via redox-dependent receptor recognition, HMGB1 demonstrates dual immunomodulatory effects, manifesting both pro-inflammatory and immunosuppressive activities

-Glucan-functionalized carriers demonstrate efficacy in inflammatory and immune-mediated disorders through biocompatibility-driven targeting (Wu et al., 2023)

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Safety Considerations Both peptides should be used under the guidance of a qualified healthcare provider

Conversely, proinflammatory Proteobacteria species have an elevated concentration in ME/CFS (191, 194)