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[28] Dysesthesia-associated adverse events, including abnormal skin sensations such as tingling or burning, were more frequent with higher-dose semaglutide than with semaglutide 2.4 mg

doi: 10.1089/ars.2011.4161

There is a suggestion that lower dosing may be helpful, Dr

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Color Changes: Unless specifically noted for a particular compound, a change in color usually signals chemical degradation

It is worth noting that tirzepatide's mechanism of slowing gastric emptying could theoretically exacerbate reflux symptoms in susceptible individuals, and acid reflux can occasionally cause throat irritation