When to seek medical attention: Severe, persistent abdominal pain radiating to the back (possible pancreatitis) Persistent vomiting preventing adequate hydration Signs of dehydration: decreased urination, dizziness, extreme thirst Severe diarrhea lasting more than 48 hours Jaundice or dark urine (suggesting biliary obstruction, which remains possible despite cholecystectomy) Patients should be reassured that most gastrointestinal side effects improve significantly within 4-8 weeks of reaching a stable dose
Mahaffey, K.W., et al., Cardiovascular outcomes with semaglutide by severity of chronic kidney disease in type 2 diabetes: the FLOW trial
For Rybelsus (oral semaglutide), store at room temperature between 68F and 77F (20C to 25C)
Phase 2 clinical trials of retatrutide have demonstrated average weight reductions exceeding 24% of body weight making it the most potent weight loss medication currently in development
Ozempic , which contains semaglutide, helps lower blood sugar by stimulating insulin production and suppressing glucagon, a hormone that raises blood sugar
however, the side effects are usually temporary and improve over time