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Increased cAMP levels act as a secondary messenger, signaling the cell to produce and release growth hormone

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By Day 45, reduced CYP expression correlated with the emergence of mesenchymal-like cells, although functional hepatocytes remained, as evidenced by continued ALB localization in immunostaining analyses

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Most of the compounds synthesized using substrate-based inhibitors approach, these compounds are proline mimetic, which occupy S 1 -pocket, P 2 -substituent of drug occupies S 2 -pocket whereas P 1 -substituent occupies S 1 -pocket of DPP-4 protease, and their basic structure interacts via either forming a covalent or non-covalent bond [36]