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Some compounding facilities and experienced researchers report safe usage for 6 to 8 weeks under strict aseptic conditions, but the conservative recommendation is to use it within 4 weeks for optimal potency

Older people or those with intestinal malabsorption may also face vitamin B12 deficiency

There are certain medical conditions where caution is needed

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It was first formally described in the scientific literature in 1993 by a team of researchers led by Sikiric and colleagues