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Many of these trials do not adhere to the standards required for high-quality clinical research, such as adequate blinding and randomization, further diminishing their credibility

KEY OBSERVATIONS Cold-chain packaging was handled properly with two ice packs wrapped in thick insulated foam, ensuring the medication arrived at the correct temperature

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Nutritional needs can vary between early use, short- or long-term use, and post-medication

Effects of low-dose, controlled-release, phentermine plus topiramate combination on weight and associated comorbidities in overweight and obese adults (CONQUER): a randomised, placebo-controlled, phase 3 trial