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Coenzyme A production: B5 contributes to coenzyme A, which is involved in fat, carbohydrate and protein metabolism

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NADPH acts as a cofactor and reducing agent for enzymes such as glutathione reductase and thioredoxin reductase, catalyzing the reduction of glutathione (GSH) and thioredoxin (Trx), respectively (Figure 1)

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Compounded versions during shortages added further safety concerns, prompting manufacturer lawsuits against some sellers.