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Presumably, the ascladiol produced can be further reduced to hydroascladiol by certain microorganisms

It doesn't contract well enough, and therefore it doesn't squeeze when you want it to, and you don't empty your bladder completely

Ferroptosis may further affect the production of inflammatory factors in synovial fibroblasts, hence hastening the breakdown of the ECM of chondrocytes [26]

Sumikawa, M

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Key observation: All dose groups began at 0.5mg with gradual escalation over several weeks before reaching maintenance doses