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As for the comparison of oral semaglutide with other oral agents, in the PIONEER 2 open-label trial, oral semaglutide (14 mg once daily) was evaluated against the sodium-glucose co-transporter 2 inhibitor (SGLT2i) empagliflozin (25 mg once daily) for 52 weeks in 822 patients with T2D uncontrolled on metformin with a mean HbA1c level of 8.1%

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Modulation of brain activity: GLP-1 receptors are active in brain regions tied to motivation and compulsive behavior

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