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NTR1 activation enhances neuronal excitability and improves spatial learning ability and memory in APP/PS1 transgenic mice [66]

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However, a prolonged half-life of more than 4 h can occur in individuals that either consume an overdose of APAP or that exhibit a clinical history of hepatic injury or chronic liver disease ( As APAP hepatotoxicity is the most common cause of acute liver failure requiring liver transplantation, a better understanding of the molecular events contributing to APAP hepatotoxicity may provide novel opportunities for intervention

Its copper-chelating properties and documented interaction with the extracellular matrix make it a reference compound for researchers studying metallopeptide biology and connective tissue signalling

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