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Additionally these complications were transient, easily treated and tolerated without treatment discontinuation

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[7] [9] Patients with a history of oxalate nephrolithiasis (kidney stones) or hyperoxaluria should avoid high-dose vitamin C administration, as ascorbic acid is metabolized to oxalate, which may precipitate stone formation or exacerbate renal impairment

Patients must take Rybelsus first thing in the morning on an empty stomach with no more than 4 ounces of plain water only, swallow the tablet whole (do not split, crush, or chew), and wait at least 30 minutes before consuming food, beverages, or other medications to ensure optimal absorption