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Intranasally delivered siRNA targeting PI3K/Akt/mTOR inflammatory pathways protects from aspergillosis

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doi: 10.1016/j.mtbio.2025.102304 405 FengYWangXLiPShiXProkoschVLiuH

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Initial studies reported that concentrations of AFB 1 which are likely to be achieved in the liver following ingestion of real-world concentrations of AFB 1 are bioactivated to AFBO primarily by CYP1A2, whereas much higher concentrations are catalyzed by CYP3A4 [30], [46], [79]

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