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At week 20, the change from baseline in HbA1c in patients treated with sitagliptin (N=107) was -0.23% compared to 0.09% in patients treated with placebo (N=113), a difference of -0.33% (95% CI: -0.70, 0.05)

The associated weight loss benefits attracted attention and between 2021 -2024 when weight-loss approvals were obtained, media coverage dramatically increased demand

Rapid weight loss can sometimes lead to a loss of lean muscle mass

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It is seen across a range of peptides and pharmaceutical compounds that carry ionic or charged components, particularly when those compounds are injected into sensitive or low-fat tissue without adequate buffering

Nat Genet 47(12):1426-34, 2015