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The evidence base for many of these interventions remains limited, uneven, or derived from non-thyroid populations ( U -shaped risk profile, with both deficiency and excess impairing thyroid and brain health ( The purpose of this review is threefold: first, to describe the pathophysiological mechanisms by which thyroid dysfunction affects the brain

demonstrated that liraglutide modulates the composition of obesity-associated gut microbiota, such as Escherichia coli , markedly restructuring the microbial community and reshaping bacterial taxa linked to body weight regulation, thereby contributing to weight reduction ( Nevertheless, there are also some contradictory results

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