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These lifestyle changes can also include practices such as cold therapy, relaxation, and meditation techniques, which have emerging evidence supporting their beneficial effects on weight management and overall metabolic health.Even a modest weight loss of 5-10% of body weight can have a significant impact on improving metabolic health and reducing the risk of chronic diseases

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259,260 However, their poor distributions in vivo and low cellular uptake are challenges for their clinical application

Adiponectin levels are diminished by sickness

Danyal, M., Shah, S.I.A., Hassan, M.S.U