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Some orthopedic surgeons may perceive the growing use of GLP-1 receptor agonists as a potential threat to their practice, fearing that widespread weight loss could reduce the volume of patients requiring joint replacements

It is also approved for blood sugar control in adults with type 2 diabetes

Regular clinical review should include: Assessment of weight loss trajectory and nutritional status Evaluation of fall risk, particularly in older adults Review of concomitant medications affecting bone health Monitoring for new fractures or bone pain When to seek medical advice : Patients should contact their GP if they experience unexplained bone pain, height loss, new fractures from minimal trauma, or concerns about rapid weight loss

Common side effects documented across GLP-1 clinical trials include nausea, vomiting, diarrhea, constipation, and injection-site reactions

Yamaguchi, E., Yasoshima, Y

GLP-1(2836) also increased glycolytic capacity in caSMCs by 35% (ECAR: 30.1 1.5 vs