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reveals that extracellular L-serine depletion in Hepa1-6 hepatoma cells activates the Atf4-mediated transcriptional program, inducing genes like ChaC1

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The molecule consists of 15 amino acids and is identified by the sequence GEPPPGKPADDAGLV , which forms the basis of its structural classification as a short peptide with a biologically active structure

Nagakura, Y., Ito, H