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Published data on lobe differences in endogenous and induced enzymes is scarce, although many researchers suspect there may be important lobe differences based on differential blood flow (Wilson and Hiley 1983) and the observation of lobe differences in toxic responses

Deficiencies in Vitamin D contribute to osteopenia and osteoporosis which affect up to 80% of SCD patients

When relief of pain from treatment with GnRH agonist supports continued therapy, the addition of add-back therapy reduces or eliminates GnRH agonist-induced bone mineral loss and provides symptomatic relief without reducing the efficacy of pain relief

Despite reperfusion reestablishing oxygenation, it paradoxically exacerbates the injury by promoting reactive oxygen species production and encouraging pro-inflammatory neutrophils to infiltrate the ischemic tissues, thereby amplifying the ischemic damage [49] (Fig

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