When a key nutrient is limiting, flux through anabolic growth-promoting processes is generally downregulated, thereby severely perturbing cellular energy homeostasis and resulting in inhibition of key enzymes such as isocitrate dehydrogenase (ICDH) (Evans and Ratledge, 1985a,b)
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Methylenetetrahydrofolate reductase polymorphism affects the change in homocysteine and folate concentrations resulting from low dose folic acid supplementation in women with unexplained recurrent miscarriages
