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It is well known that high tissue tumor mutational burden (TMB) could be a useful marker to recognize patients with recurrent or metastatic advanced solid tumors who will have a better therapeutic benefit from immune checkpoint inhibitors, such as pembrolizumab [40]

TB-500: 5 mg per week split into 2 to 3 doses for 6 weeks, then 2 to 3 mg per week for 4 weeks maintenance

In addition, for other unclear reasons, obesity drugs were generally less effective in patients with type 2 diabetes than in in people without diabetes [5]

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