129 Notably, Yu et al 130 demonstrated that the CYP2E1 c1/c1 genotype amplifies the risk of HCC in smokers, further exacerbated by alcohol intake, highlighting the significant influence of genegene and geneenvironment interactions
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Ecotox 18:385402 Hahn ME, Hestermann EV (2008) Receptor-mediated mechanisms of toxicity