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In rare cases, sexual dysfunction may develop as an adverse effect and persist in some male patients months after isotretinoin therapy

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The imbalance of energy metabolism caused by excitotoxicity is also one of the pivotal causes of cell death

Effective treatments for neurological disorders are still lacking, primarily due to the presence of the blood-brain barrier (BBB), a unique and selective endothelial barrier that protects against neurotoxic substances, as well as prevents the movement of xenobiotics into the CNS, including pharmacological agents (Crowe et al., 2018)

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