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Following cellular uptake, Ag NPs accumulate within the mitochondria and induce mitochondrial membrane depolarization via excessive generation of reactive oxygen species (ROS) [100]

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The purified recombinant MhTyrA p Q227E enzyme (Figure S3) showed decreased PDH activity (Figure 4D) with a substantial gain of ADH activity (Figure 4C, Table 1) without altering cofactor preference (Figure S4)

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