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No damage
The 12mg maximum is lower than tirzepatide but achieves greater efficacy, demonstrating that three receptor targets provide synergistic effects beyond what raw dosing would suggest
However, patients with cortical superficial siderosis were at increased risk of recurrent ICH (OR 7.7, 95% CI 1.4-42.2)
Taken together these findings encourage new clinically relevant approaches to understanding the memory enhancing effects, especially of the angiotensin IV system, on cerebral blood flow, neuroprotection, stress and depression, alcohol consumption, seizure, Alzheimers and PDs, and diabetes (172, 173)