I met Amanda who immediately put me at ease and made me feel very welcome
United Kingdom prospective diabetes study 24: a 6-year, randomized, controlled trial comparing sulfonylurea, insulin, and metformin therapy in patients with newly diagnosed type 2 diabetes that could not be controlled with diet therapy
Our results indicate that no significant differences were suggested for PE (HR = 1.20, 95% CI = 0.881.64), stroke (HR = 1.14, 95% CI = 0.881.49), heart failure (HR = 1.16, 95% CI = 0.981.38), or MI (HR = 1.27, 95% CI = 0.901.78) (Fig 6)
Instead of asking 'why not stack them,' the question becomes 'what specific outcome justifies adding a second compound with incomplete human safety data?' For research exploring maximal metabolic intervention where single-agent tirzepatide has plateaued, the stack may be defensible
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Aburel OM, Brescu L, Buriman DG, Merce AP, Bn AM, Borza C, Morno C, Sturza A, Muntean DM (2024) Methylene blue reduces monoamine oxidase expression and oxidative stress in human cardiovascular adipose tissue
