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Rare but serious concerns include pancreatitis and thyroid C-cell changes (in rodent studies, not confirmed in humans)

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Animal studies demonstrate that dihydrotestosterone (DHT) treatment upregulates ferroptosis-related markers ( e.g ., ACSL4) in ovarian cells, suggesting that androgens may exacerbate ferroptosis by modulating lipid metabolism genes ( 3.4 Epigenetic modifications Growing evidence has elucidated the critical role of epigenetic modifications in the pathogenesis and progression of PCOS

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(Source) Pancreatitis: Studies suggest that Ozempic use has been associated with an increase in reports of acute pancreatitis, which can be fatal in some cases