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When gut bacteria ferment fiber and produce butyrate, it signals specialized cells in the gut lining to release GLP-1, a hormone involved in appetite and blood sugar control

Starting with high doses (1,000 mcg to 2,000 mcg) weekly or biweekly is common

This discovery led to the development of exenatide, which in 2005 became the first GLP-1 receptor agonist approved by the FDA for the treatment of type 2 diabetes (T2DM)

Lodder, E

Limited access can delay or complicate progress