Direct evidence of DJ-1s role in neuronal survival against ferroptosis comes from studies showing that dopaminergic neurons differentiated from induced pluripotent stem cells of PARK7 mutant carriers exhibit increased sensitivity to ferroptosis (93)
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Analogously, in the context of OA, it is speculated that local ferroptosis in joints may release metabolites such as pro-inflammatory factors and LPO into the bloodstream, thereby regulating the compositional and structural features of the gut microbiota