Increased plasma levels of the methylglyoxal in patients with newly diagnosed type 2 diabetes 2
Funding The research was supported in part by Grants-in-Aid for Challenging Exploratory Research and Scientific Research (B) from the Japan Society for the Promotion of Science (JSPS KAKENHI Grant Numbers JP26660218, JP21H02347, and JP24K01911, respectively) and by grant funds from the Uehara Memorial Foundation and Ito Foundation (all to R
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The mechanism: IGF-1 receptor activation in renal tubules increases sodium reabsorption, expanding plasma volume and driving fluid into interstitial spaces
