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Conjugating TEM8-targeting antibodies with cytotoxic monomethyl auristatin E was successful in specifically directing the drug to the tumor microenvironment of orthotopic tumors and patient derived xenografts, significantly inducing regression or eradication of tumor growth in pre-clinical models [323]

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Endometriosis increases the risk of certain gynecologic cancers, particularly ovarian cancer, and any medication that modulates the endometrial environment needs cancer risk assessment

While short-term, low-dose use may be acceptable for pain management, prolonged NSAID use during the early weeks of fracture healing has been associated with delayed union in some studies