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Moreover, the ER stress-induced activation of protein kinase R upregulates p62 that, as previously mentioned, is able to compete with Keap1 for Nrf2 binding, to stabilise Nrf2 [147]

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Additionally, GLP-1 slows gastric emptying, thereby reducing the speed at which glucose enters the bloodstream after meals

In particular, TMAO is accumulated in one half the concentration of urea in shallow-sea elasmobranchs to counteract the deleterious effects of urea on cellular proteins (Seibel and Walsh, 2002)