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These aging-related skin issues can also occur prematurely due to a range of internal and external factors

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In both in vitro (0.5 M for 24 h) and in vivo (141 mol/kg/day for 14 days) settings, SF mitigated high glucose-induced apoptosis by inhibiting the upregulation of apoptotic markers and the downregulation of antiapoptotic maker Bcl-2 protein in hippocampal neurons exposed to high glucose (126)

Together, these results show that RSL3 treatment is well tolerated and can eliminate senescent cells in vivo

The following letter grades are based on the evidence quality criteria proposed by the American Academy of Pediatrics: A = well-designed RCTs or diagnostic studies on relevant populations