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Some patients may experience transient changes in blood pressure, though long-term cardiovascular outcomes studies have generally shown beneficial or neutral effects of GLP-1 receptor agonists on cardiovascular events

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In states of obesity and metabolic dysfunction, NNMT is often overexpressed in adipose tissue, depleting nicotinamide and reducing NAD+ availability [2]

Metformin-induced vitamin B12 deficiency can cause or worsen distal symmetrical, autonomic and cardiac neuropathy in the patient with diabetes