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Among the possible mechanisms contributing to the anti-tumoral effect of metformin in TC, a TSH-lowering effect can be observed in patients treated with metformin, for several clinical condition (Rotondi et al., 2011

DM control

The time points at which weight regain was reported varied significantly across studies

This approach would typically involve close monitoring by a healthcare provider to ensure that the lower doses are still effective in managing blood sugar and that the patient remains safe from potential side effects

However, ongoing safety monitoring on Hers depends on patient-initiated check-ins rather than mandatory follow-up labs or clinical assessments, which may delay detection of dose-related complications or emerging health concerns

Lastly, the theoretical net charge of the proteins was determined as a function of pH (pH 1.013.9) (Supplementary Fig